The Cape Floristic Region is a floristic region located near the southern tip of South Africa. It is the only floristic region of the Cape (South African) Floristic Kingdom, and includes only one floristic province, known as the Cape Floristic Province.

The Cape Floristic Region, the smallest of the six recognised floral kingdoms of the world, is an area of extraordinarily high diversity and endemism, and is home to more than 9 000 vascular plant species, of which 69 percent are endemic. Much of this diversity is associated with the fynbos biome, a Mediterranean-type, fire-prone shrubland. The economical worth of fynbos biodiversity, based on harvests of fynbos products (e.g. wildflowers) and eco-tourism, is estimated to be in the region of R77 million a year. Thus, it is clear that the Cape Floristic Region has both economic and intrinsic biological value as a biodiversity hotspot.

Home to the greatest non-tropical concentration of higher plant species in the world, the region is the only hotspot that encompasses an entire floral kingdom, and holds five of South Africa’s 12 endemic plant families and 160 endemic genera. Covering 78,555 km², Cape Floristic Region hotspot is located entirely within the borders of South Africa. It is one of the five temperate Mediterranean-type systems on the hotspots list, and is one of only two hotspots that encompass an entire floral kingdom (the other being New Caledonia)[citation needed]. The Region covers the Mediterranean climate region of South Africa in the Western Cape in the southwestern corner of the country, and extends eastward into the Eastern Cape, a transitional zone between the winter rainfall region to the west and the summer-rainfall region to the east in KwaZulu-Natal.